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RAG2 monoclonal antibody, clone 4D5

  • Catalog # : MAB10311
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant RAG2.
  • Immunogen:
  • Recombinant protein corresponding to amino acids 350-527 of human RAG2.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 59
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Recommend Usage:
  • ELISA (1:10000)
    Western Blot (1:500-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In ascites (0.03% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western blot analysis using RAG2 monoclonal antobody, clone 4D5 (Cat # MAB10311) against RAG2-hIgGFc transfected HEK293 cell lysate.
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 5897
  • Gene Name:
  • RAG2
  • Gene Alias:
  • RAG-2
  • Gene Description:
  • recombination activating gene 2
  • Gene Summary:
  • This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq
  • Other Designations:
  • V(D)J recombination-activating protein 2
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