RAG2 monoclonal antibody, clone 4D5
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis using RAG2 monoclonal antobody, clone 4D5 (Cat # MAB10311) against RAG2-hIgGFc transfected HEK293 cell lysate.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant RAG2.
Immunogen
Recombinant protein corresponding to amino acids 350-527 of human RAG2.
Host
Mouse
Theoretical MW (kDa)
59
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (0.03% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis using RAG2 monoclonal antobody, clone 4D5 (Cat # MAB10311) against RAG2-hIgGFc transfected HEK293 cell lysate.Enzyme-linked Immunoabsorbent Assay
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Gene Info — RAG2
Entrez GeneID
5897Gene Name
RAG2
Gene Alias
RAG-2
Gene Description
recombination activating gene 2
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq
Other Designations
V(D)J recombination-activating protein 2
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Interactome
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Pathway
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Disease
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