TP63 monoclonal antibody, clone 4E5
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of TP63.
Immunogen
A synthetic peptide corresponding to human TP63.
Sequence
CARRNKQQRIKEEGE
Host
Mouse
Theoretical MW (kDa)
51
Reactivity
Human, Monkey, Mouse, Rat
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (0.03% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis using TP63 monoclonal antobody, clone 4E5 (Cat # MAB10290) against A-431 (1), HeLa (2), Jurkat (3), THP-1 (4), NIH/3T3 (5), COS-7 (6) and PC-12 (7) cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human ovarian cancer (A) and lung cancer (B) using TP63 monoclonal antobody, clone 4E5 (Cat # MAB10290) with DAB staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TP63
Entrez GeneID
8626Gene Name
TP63
Gene Alias
AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L
Gene Description
tumor protein p63
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq
Other Designations
amplified in squamous cell carcinoma|chronic ulcerative stomatitis protein|keratinocyte transcription factor|transformation-related protein 63|tumor protein p53-competing protein|tumor protein p53-like|tumor protein p73-like
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Interactome
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Disease
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