Immunohistochemical analysis of paraffin-embedded human colon tissue (A), colon cancer tissue (B), stomach tissue (C) and brain tissue (D) using OTX2 monoclonal antobody, clone 1H12G8B2 (Cat # MAB10289) with DAB staining.
Immunofluorescence analysis of U251 cells using OTX2 monoclonal antobody, clone 1H12G8B2 (Cat # MAB10289) (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined. [provided by RefSeq
OTTHUMP00000064776,homeobox protein OTX2,orthodenticle homolog 2