Mouse monoclonal antibody raised against of ITGA2B.
Leukocytes of patient suffering from LGL-type leukaemia.
Theoretical MW (kDa):
ITGA2B (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). ITGA2B is mainly expressed on platelets and megakaryocytes.
Size-exclusion chromatography purification
Flow Cytometry (10 uL reagent/100 uL of whole blood or 106 cells) The optimal working dilution should be determined by the end user.
In PBS (0.2% BSA, 0.09% sodium azide)
Store at 4°C. Do not freeze.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
integrin alpha 2b,platelet fibrinogen receptor, alpha subunit,platelet-specific antigen BAK