Product Browser

Last updated: 2016/12/11
  • Related Product Showcase
  • By Application

Product Compare

Product Compare Cancel Click this icon to add products to compare list. Select up to 10 products.

Quick Order (Tutorial)

Input Catalog #,
place order here!
Catalog # :
  • Where to buy
  • Choose your location

KIR2DL4 monoclonal antibody, clone mAb#33

  • Catalog # : MAB10178
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against KIR2DL4.
  • Immunogen:
  • NK3.3 cells and human KIR2DL4-Ig fusion protein.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 45
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (1 ug/ml)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
    Avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunocytochemistry
  • Immunoprecipitation
  • Functional Study
  • Flow Cytometry
  • Application Image
  • Western Blot
  • Immunocytochemistry
  • Immunoprecipitation
  • Functional Study
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3805
  • Gene Name:
  • KIR2DL4
  • Gene Alias:
  • CD158D,G9P,KIR103,KIR103AS
  • Gene Description:
  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
  • Gene Summary:
  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq
  • Other Designations:
  • NK cell receptor,OTTHUMP00000068610,natural killer cell inhibitory receptor
  • RSS
  • YouTube
  • Linkedin
  • Facebook