KIR2DL4 monoclonal antibody, clone mAb#33
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Specification
Product Description
Mouse monoclonal antibody raised against KIR2DL4.
Immunogen
NK3.3 cells and human KIR2DL4-Ig fusion protein.
Host
Mouse
Theoretical MW (kDa)
45
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Flow Cytometry (1 ug/ml)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot
Immunocytochemistry
Immunoprecipitation
Functional Study
Flow Cytometry
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Gene Info — KIR2DL4
Entrez GeneID
3805Gene Name
KIR2DL4
Gene Alias
CD158D, G9P, KIR103, KIR103AS
Gene Description
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
Omim ID
604945Gene Ontology
HyperlinkGene Summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
NK cell receptor|OTTHUMP00000068610|natural killer cell inhibitory receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.
Guoxu Zheng, Zhangyan Guo, Weimiao Li, Wenjin Xi, Baile Zuo, Rui Zhang, Weihong Wen, An-Gang Yang, Lintao Jia.
Signal Transduction and Targeted Therapy 2021 Jun; 6(1):236.
Application:Blocking, Flow Cyt, Func, Human, BT-474 cells, Human nature killer cells, SK-BR-3 cells.
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Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.
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