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TYMS monoclonal antibody, clone SP112

  • Catalog # : MAB10056
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic peptide of TYMS.
  • Immunogen:
  • A synthetic peptide corresponding to C-terminus of human TYMS.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 36
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A/G purification
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.6 (1% BSA, 0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of paraffin-embedded human colon adenocancer sections with TYMS monoclonal antibody, clone SP112 (Cat # MAB10056).
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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  • Gene Information
  • Entrez GeneID:
  • 7298
  • Gene Name:
  • TYMS
  • Gene Alias:
  • HsT422,MGC88736,TMS,TS,TSase
  • Gene Description:
  • thymidylate synthetase
  • Gene Summary:
  • Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq
  • Other Designations:
  • Thymidylate synthase
  • Related Disease
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