Immunohistochemical staining of paraffin-embedded human tonsil sections with MPO monoclonal antibody, clone SP72 (Cat # MAB10028). Intravascular and extravascular neutrophils are stained strongly and lymphocytes are negative.
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq