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Last updated: 2016/11/27
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AXIN1 monoclonal antibody, clone AT1A4

  • Catalog # : MAB10012
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant AXIN1.
  • Immunogen:
  • Recombinant protein corresponding to amino acids 546-752 of human AXIN1.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Concentration:
  • 1 mg/mL
  • Isotype:
  • IgG2b, kappa
  • Recommend Usage:
  • Western Blot (1:250-1:500)
    Immunofluorescence (1:250-1:500)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Western Blot
  • Immunoprecipitation (Lane 1 and 2) and Western blot (Lane 3, 4 and 5) analysis in various cells and tissue extracts with AXIN1 monoclonal antibody, clone AT1A4 (Cat # MAB10012) at 1:500 dilution.
    Lane 1, normal IgG.
    Lane 2, HeLa.
    Lane 3, HeLa.
    Lane 4, AGS.
    Lane 5, SW480.
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence staining of human HeLa cells was done with Hoechst 33342 (Blue) for chromatin staining and Texas Red (Red) with AXIN1 monoclonal antibody, clone AT1A4 (Cat # MAB10012) at 1:500 dilution.
  • Immunoprecipitation
  • ELISA
  • Application Image
  • Immunoprecipitation
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 8312
  • Gene Name:
  • AXIN1
  • Gene Alias:
  • AXIN,MGC52315
  • Gene Description:
  • axin 1
  • Gene Summary:
  • This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
  • Other Designations:
  • axis inhibition protein 1,axis inhibitor 1,fused, mouse, homolog of
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