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MMP13 monoclonal antibody, clone M66

  • Catalog # : MAB10000
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant MMP13.
  • Immunogen:
  • Recombinant protein corresponding to human MMP13.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Based on ELISA, the antibody reacts with human procollagenase-3.
    The antibody does not cross react with MT1-MMP latent form (MMP14), MT2-MMP cat. domain (MMP15), MT3-MMP cat. domain (MMP16), MT4-MMP cat. domain (MMP17), MT5-MMP cat. domain (MMP18), Gelatinase A (MMP2) latent form, Gelatinase B (MMP9) latent form, Collagenase 2 (MMP8) latent form.
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Isotype:
  • IgG1
  • Recommend Usage:
  • ELISA (1:2000)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM Na-phosphate, 150 mM NaCl, pH 7.5 (0.01% thimerosal)
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • ELISA
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 4322
  • Gene Name:
  • MMP13
  • Gene Alias:
  • CLG3
  • Gene Description:
  • matrix metallopeptidase 13 (collagenase 3)
  • Gene Summary:
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
  • Other Designations:
  • collagenase 3,matrix metalloproteinase 13,matrix metalloproteinase 13 (collagenase 3)
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