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Last updated: 2017/8/13
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DFFB monoclonal antibody, clone 4B8

  • Catalog # : MAB0999
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant DFFB.
  • Immunogen:
  • Recombinant His fusion protein corresponding to full length human DFFB.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Ammonium sulfate precipitation
  • Isotype:
  • IgG2a, kappa
  • Recommend Usage:
  • Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Enzyme-linked Immunoabsorbent Assay
  • Application Image
  • Western Blot
  • Enzyme-linked Immunoabsorbent Assay
  • Gene Information
  • Entrez GeneID:
  • 1677
  • Gene Name:
  • DFFB
  • Gene Alias:
  • CAD,CPAN,DFF-40,DFF2,DFF40
  • Gene Description:
  • DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
  • Gene Summary:
  • Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq
  • Other Designations:
  • DNA fragmentation factor, 40 kD, beta polypeptide,DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase),DNA fragmentation factor, 40 kD, beta subunit,OTTHUMP00000003633,caspase-activated deoxyribonuclease,caspase-activated nuclease
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