ICAM3 monoclonal antibody, clone MEM-04
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Specification
Product Description
Mouse monoclonal antibody raised against native ICAM3.
Immunogen
Native purified ICAM3 from leukocytes of a patient suffering from a LGL-type leukemia.
Host
Mouse
Theoretical MW (kDa)
120-130
Reactivity
Human
Specificity
This antibody reacts with CD50 (ICAM-3), a 120-130 KDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes.
The MEM-04 blocks DC-SIGN (CD209) binding to ICAM-3 (epitope in D1).Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing. -
Applications
Flow Cytometry
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Gene Info — ICAM3
Entrez GeneID
3385Gene Name
ICAM3
Gene Alias
CD50, CDW50, ICAM-R
Gene Description
intercellular adhesion molecule 3
Omim ID
146631Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. [provided by RefSeq
Other Designations
intercellular adhesion molecule-3
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Interactome
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Pathway
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Disease
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