Mouse monoclonal antibody raised against native ICAM3.
Native purified ICAM3 from leukocytes of a patient suffering from a LGL-type leukemia.
Theoretical MW (kDa):
This antibody reacts with CD50 (ICAM-3), a 120-130 KDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes. The MEM-04 blocks DC-SIGN (CD209) binding to ICAM-3 (epitope in D1).
The optimal working dilution should be determined by the end user.
In PBS, pH 7.4
Store at 4°C. Do not freeze. Aliquot to avoid repeated freezing and thawing.
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. [provided by RefSeq