Mouse monoclonal antibody raised against native FCGR3A.
Native purified FCGR3A from normal human peripheral blood granulocytes.
Theoretical MW (kDa):
This antibody reacts with CD16, a low affinity receptor for aggregated IgG (Fc gamma RIII antigen). CD16 exists in two different isoforms: CD16a (Fc gamma RIIIA; 50-65 KDa; expressed on NK-cells, monocytes and macrophages) and CD16b (Fc gamma RIIIB; 48 KDa; mainly expressed on neutrophils).
The optimal working dilution should be determined by the end user.
In TBS, pH 8.0 (0.09% sodium azide)
Store at 4°C. Do not freeze. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Fc fragment of IgG, low affinity III, receptor for (CD16),Fc fragment of IgG, low affinity IIIa, receptor for (CD16),Fc gamma receptor III-A,Fc-gamma RIII-alpha,Fc-gamma RIIIa,Fc-gamma receptor III-2 (CD 16),Fc-gamma receptor IIIb (CD16),FcgammaRIIIA,OTTH