Immunofluorescence staining of CD63 in human HeLa cell line using CD63 monoclonal antibody, clone MEM-259 (Cat # MAB0931, green). Actin cytoskeleton was decorated by phalloidin (red) and cell nuclei stained with DAPI (blue) .
Immunofluorescence staining of (A) human skin fibroblasts and (B) human primary fibroblasts with CD63 monoclonal antibody, clone MEM-259 (Cat # MAB0931, green) after co-incubation of living cells with human Transferrin-Dyomics 547 (red) ; cell nuclei stained with DAPI (blue) .
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq