ITGB2 monoclonal antibody, clone MEM-148
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Specification
Product Description
Mouse monoclonal antibody raised against native ITGB2.
Immunogen
Native purified ITGB2 from peripheral blood mononuclear cells.
Host
Mouse
Theoretical MW (kDa)
90-95
Reactivity
Human
Specificity
This antibody MEM-148 recognizes the epitope exposed on free human CD18 chains unassociated with CD11 as well as on high-affinity state of LFA-1. CD18 (integrin beta2 subunit; beta2 integrin) is a 90-95 KDa type I transmembrane protein expressed on all leukocytes.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blotting analysis of PMA - activated neutrophils (A) and monocytes (B) , using ITGB2 monoclonal antibody, clone MEM - 148 (Cat # MAB0929) . The antibody MEM - 148 recognizes the lower 65 to 70 kDa zone (activation marker) as well as the upper 78 to 96 kDa zone (ITGB2) .Immunoprecipitation
Flow Cytometry
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Gene Info — ITGB2
Entrez GeneID
3689Gene Name
ITGB2
Gene Alias
CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
Gene Description
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq
Other Designations
CD18 subunit|OTTHUMP00000115278|OTTHUMP00000115279|OTTHUMP00000115281|OTTHUMP00000115282|beta 2 integrin subunit|cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)|complement receptor C3 beta-subunit|integrin beta 2|integrin bet
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Interactome
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Disease
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