LCK monoclonal antibody, clone LCK-01
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blotting analysis (reducing conditions) of human LCK in whole cell lysate using LCK monoclonal antibody, clone LCK - 01 (Cat # MAB0912) . Lane 1 : J. CaM - 1.6 cell line (a mutant derivate of the Jurkat cell line) transfected with LCK. Lane 2 : HEK 293T cell line transfected with LCK. Lane 3 : HEK 293T cell line (non - transfected) .
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of LCK.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 22-36 of human LCK.
Host
Mouse
Theoretical MW (kDa)
56
Reactivity
Human
Specificity
This antibody LCK-01 recognizes defined epitope of Lck, a 56 KDa Src-family protein tyrosine kinase.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blotting analysis (reducing conditions) of human LCK in whole cell lysate using LCK monoclonal antibody, clone LCK - 01 (Cat # MAB0912) . Lane 1 : J. CaM - 1.6 cell line (a mutant derivate of the Jurkat cell line) transfected with LCK. Lane 2 : HEK 293T cell line transfected with LCK. Lane 3 : HEK 293T cell line (non - transfected) .Immunocytochemistry
Immunoprecipitation
Flow Cytometry
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Gene Info — LCK
Entrez GeneID
3932Gene Name
LCK
Gene Alias
YT16, p56lck, pp58lck
Gene Description
lymphocyte-specific protein tyrosine kinase
Omim ID
153390Gene Ontology
HyperlinkGene Summary
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq
Other Designations
T-lymphocyte specific protein tyrosine kinase p56lck|p56(LSTRA) protein-tyrosine kinase|protein tyrosine kinase|proto-oncogene tyrosine-protein kinase LCK
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Interactome
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Pathway
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Disease
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