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Last updated: 2022/5/22
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KRT5/KRT8 monoclonal antibody, clone C-50 

  • Catalog # : MAB0853
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native KRT5/KRT8.
  • Immunogen:
  • Cytoskeleton preparation from HeLa cells.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 58, 53
  • Reactivity:
  • Dog, Hamster, Human, Mouse, Rat, Sheep
  • Specificity:
  • The antibody C-50 reacts with cytokeratin peptides 5 and 8 (58 and 53 kDa). Cytokeratins are members of intermediate filaments subfamily of intracellular proteins represented in epithelial tissues.
  • Form:
  • Liquid
  • Purification:
  • Protein-A affinity chromatography
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Immunocytochemistry
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL; positive control: human prostate.)
    Immunoprecipitation
    Western Blot
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (15 mM sodium azide).
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunocytochemistry
  • Immunoprecipitation
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunocytochemistry
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 3852
  • Gene Name:
  • KRT5
  • Gene Alias:
  • CK5,DDD,EBS2,K5,KRT5A
  • Gene Description:
  • keratin 5
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq
  • Other Designations:
  • 58 kda cytokeratin,epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types,keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types),keratin, type II cytoskeletal 5
  • Gene Information
  • Entrez GeneID:
  • 3856
  • Gene Name:
  • KRT8
  • Gene Alias:
  • CARD2,CK8,CYK8,K2C8,K8,KO
  • Gene Description:
  • keratin 8
  • Gene Summary:
  • This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq
  • Other Designations:
  • cytokeratin 8,keratin, type II cytoskeletal 8
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