Immunoprecipitation analysis of cell and tissue lysates. Lane 1 : Input, lane 2 : Precipitates (HepG2) and lane 3 : Precipitates (mouse liver). Immunoblotting with MSRA monoclonal antibody, clone 1C8 (Cat # MAB0727).
This protein is ubiquitous and highly conserved. It carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. Its proposed function is the repair of oxidative damage to proteins to restore biological activity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
cytosolic methionine-S-sulfoxide reductase,peptide met (O) reductase