ANTXR1 monoclonal antibody, clone 200C1339(SB20)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot detection of TEM8 in TEM8 transfected 293 cell lysate. Using ANTXR1 monoclonal antibody, clone 200C1339 (SB20) (Cat # MAB0108) at 1 ug/mL .
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of ANTXR1.
Immunogen
A synthetic peptide corresponding to amino acids 481-497 of human ANTXR1.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G chromatography
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot detection of TEM8 in TEM8 transfected 293 cell lysate. Using ANTXR1 monoclonal antibody, clone 200C1339 (SB20) (Cat # MAB0108) at 1 ug/mL .Immunohistochemistry
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Gene Info — ANTXR1
Entrez GeneID
84168Gene Name
ANTXR1
Gene Alias
ATR, FLJ10601, FLJ11298, FLJ21776, TEM8
Gene Description
anthrax toxin receptor 1
Omim ID
606410Gene Ontology
HyperlinkGene Summary
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq
Other Designations
2310008J16Rik|2810405N18Rik|tumor endothelial marker 8
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Interactome
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Publication Reference
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Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton.
Werner E, Kowalczyk AP, Faundez V.
The Journal of Biological Chemistry 2006 Jun; 281(32):23227.
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TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen.
Hotchkiss KA, Basile CM, Spring SC, Bonuccelli G, Lisanti MP, Terman BI.
Experimental Cell Research 2005 Apr; 305(1):133.
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TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI).
Nanda A, Carson-Walter EB, Seaman S, Barber TD, Stampfl J, Singh S, Vogelstein B, Kinzler KW, St Croix B.
Cancer Research 2004 Feb; 64(3):817.
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Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton.
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