Western blot detection of HTRA2 in HL-60 cell lysate. Two protein bands of approximate molecular weight of 50 and 38 KDa were detected using HTRA2 monoclonal antibody, clone 196C429 (Cat # MAB0099) at 3 ug/mL dilution. The 50 KDa and 38 KDa bands may represent precursor and mature form of Omi.
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq
HtrA-like serine protease,Omi stress-regulated endoprotease,high temperature requirement protein A2,protease, serine, 25