PMAIP1 monoclonal antibody, clone 114C307.1
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot detection of PMAIP1 in RL-7 cell (a follicular lymphoma) lysate. A protein of approximate molecular weight of 11 KDa is detected. Using PMAIP1 monoclonal antibody, clone 114C307.1 (Cat # MAB0093) at 2 ug/mL.
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant PMAIP1.
Immunogen
Recombinant GST fusion protein corresponding to full length human PMAIP1.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot detection of PMAIP1 in RL-7 cell (a follicular lymphoma) lysate. A protein of approximate molecular weight of 11 KDa is detected. Using PMAIP1 monoclonal antibody, clone 114C307.1 (Cat # MAB0093) at 2 ug/mL.Immunocytochemistry
Immunofluorescence
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Gene Info — PMAIP1
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Interactome
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Pathway
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Publication Reference
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Inhibition of apoptosis facilitates necrosis induced by cisplatin in gastric cancer cells.
Zhang LJ, Hao YZ, Hu CS, Ye Y, Xie QP, Thorne RF, Hersey P, Zhang XD.
Anticancer Drugs 2008 Feb; 19(2):159.
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Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.
Tahir SK, Yang X, Anderson MG, Morgan-Lappe SE, Sarthy AV, Chen J, Warner RB, Ng SC, Fesik SW, Elmore SW, Rosenberg SH, Tse C.
Cancer Research 2007 Feb; 67(3):1176.
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Inhibition of glutathione synthesis overcomes Bcl-2-mediated topoisomerase inhibitor resistance and induces nonapoptotic cell death via mitochondrial-independent pathway.
Yoshida A, Takemura H, Inoue H, Miyashita T, Ueda T.
Cancer Research 2006 Jun; 66(11):5772.
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Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.
Xie W, Jiang P, Miao L, Zhao Y, Zhimin Z, Qing L, Zhu WG, Wu M.
Nucleic Acids Research 2006 Apr; 34(7):2046.
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Id3 induces a caspase-3- and -9-dependent apoptosis and mediates UVB sensitization of HPV16 E6/7 immortalized human keratinocytes.
Simbulan-Rosenthal CM, Daher A, Trabosh V, Chen WC, Gerstel D, Soeda E, Rosenthal DS.
Oncogene 2006 Jan; 25(26):3649.
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Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
Wen Yong Chen, David H Wang, Raywhay Chiu Yen, Jianyuan Luo, Wei Gu, Stephen B Baylin.
Cell 2005 Nov; 123(3):437.
Application：WB-Tr, Human, MCF-7 cells.
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In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation.
Erster S, Mihara M, Kim RH, Petrenko O, Moll UM.
Molecular and Cellular Biology 2004 Aug; 24(15):6728.
Application：WB, Mouse , Mouse thymus.
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BOK and NOXA are essential mediators of p53-dependent apoptosis.
Alexander G Yakovlev, Simone Di Giovanni, Geping Wang, Wenfan Liu, Bogdan Stoica, Alan I Faden.
The Journal of Biological Chemistry 2004 Jul; 279(27):28367.
Application：WB-Ce, WB-Tr, Human, MCF-7, SH-SY5Y cells.
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p53 has a direct apoptogenic role at the mitochondria.
Motohiro Mihara, Susan Erster, Alexander Zaika, Oleksi Petrenko, Thomas Chittenden, Petr Pancoska, Ute M Moll.
Molecular Cell 2003 Mar; 11(3):577.
Application：WB-Tr, Human, NCI-H1299 cells.
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Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage.
Benjamin E Deverman, Brian L Cook, Scott R Manson, Robert A Niederhoff, Ellen M Langer, Ivana Rosova, Laura A Kulans, Xiaoyun Fu, Justin S Weinberg, Jay W Heinecke, Kevin A Roth, Steven J Weintraub.
Cell 2002 Oct; 111(1):51.
Application：WB-Ce, WB-Tr, Human, Normal human diploid fibroblasts.
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Inhibition of apoptosis facilitates necrosis induced by cisplatin in gastric cancer cells.
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