CD molecules 2006--human cell differentiation molecules. Zola H, Swart B, Banham A, Barry S, Beare A, Bensussan A, Boumsell L, D Buckley C, Buhring HJ, Clark G, Engel P, Fox D, Jin BQ, Macardle PJ, Malavasi F, Mason D, Stockinger H, Yang X.J Immunol Methods. 2007 Jan 30;319(1-2):1-5. Epub 2006 Dec 4.
Immunohistochemical analysis of TLR8 in paraffin-embedded formalin-fixed human brain tissue using an isotype control (top) and TLR8 monoclonal antibody, clone 44C143 (Cat # MAB0089) (bottom) at 5 ug/mL .
Intracellular flow analysis of TLR8 in 1x10^6 Ramos cells. Using 0.5 ug of TLR8 monoclonal antibody, clone 44C143 (Cat # MAB0089) histogram represents Ramos cells without antibody; Green represents isotype control (Sigma, Cat. No. M5284) ; red represents anti-TLR8 antibody.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq