Immunohistochemical analysis of TLR6 in paraffin-embedded formalin-fixed human liver tissue using an isotype control (top) and TLR6 monoclonal antibody, clone 86B1153.2 (Cat # MAB0086) (bottom) at 5 ug/mL .
Intracellular FACS analysis of TLR6 (shaded peak) and mouse IgG1 isotype control (open peak) in 10^6 Ramos cells using 3 ugs of TLR6 monoclonal antibody, clone 86B1153.2 (Cat # MAB0086).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. [provided by RefSeq