RAD9A monoclonal antibody, clone 93A535
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant RAD9A.
Immunogen
Recombinant protein corresponding to full length human RAD9A.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis of RAD9A. Using RAD9A monoclonal antibody, clone 93A535 (Cat # MAB0063) at 2 ug/mL against recombinant RAD9.Immunocytochemistry
Immunofluorescence
Immunoprecipitation
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Gene Info — RAD9A
Entrez GeneID
5883Gene Name
RAD9A
Gene Alias
RAD9
Gene Description
RAD9 homolog A (S. pombe)
Omim ID
603761Gene Ontology
HyperlinkGene Summary
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene. [provided by RefSeq
Other Designations
RAD9 homolog|cell cycle checkpoint control protein
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Interactome
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Disease
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Publication Reference
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The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase.
Guan X, Madabushi A, Chang DY, Fitzgerald ME, Shi G, Drohat AC, Lu AL.
Nucleic Acids Research 2007 Sep; 35(18):6207.
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Protein expression profiling and molecular classification of gastric cancer by the tissue array method.
Lee HS, Cho SB, Lee HE, Kim MA, Kim JH, Park do J, Kim JH, Yang HK, Lee BL, Kim WH.
Clinical Cancer Research 2007 Jul; 13(14):4154.
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Epstein-barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with epstein-barr virus-negative carcinoma.
Lee HS, Chang MS, Yang HK, Lee BL, Kim WH.
Clinical Cancer Research 2004 Mar; 10(5):1698.
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PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition.
Komatsu K, Wharton W, Hang H, Wu C, Singh S, Lieberman HB, Pledger WJ, Wang HG.
Oncogene 2000 Nov; 19(46):5291.
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The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase.
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