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Entrez GeneID

Gene Name

CSH1

Gene Alias

CSA, CSMT, FLJ75407, PL

Gene Description

chorionic somatomammotropin hormone 1 (placental lactogen)

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq

Other Designations

CS-1|choriomammotropin|chorionic somatomammotropin A|chorionic somatomammotropin hormone 1|hCS-A|placental lactogen

Entrez GeneID

Gene Name

ITGA4

Gene Alias

CD49D, IA4, MGC90518

Gene Description

integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

Omim ID

Gene Ontology

Gene Summary

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq

Other Designations

269C wild type|antigen CD49D, alpha-4 subunit of VLA-4 receptor|integrin alpha 4|integrin alpha-4 subunit|very late activation protein 4 receptor, alpha 4 subunit