UCHL1 Deubiquitinase Inhibitor Screening Kit utilizes the ability of active UCH-L1 deubiquitinase to cleave a synthetic protein substrate to release the free fluorophore, which can be easily quantified (Ex/Em = 350/440 nm) using a fluorescence microplate reader.
Storage Instruction:
Store the kit at -20°C. Avoid repeated freezing and thawing.
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease