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Last updated: 2022/5/15

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LATS1 (Human) ELISA Kit 

  • Catalog # : KA6398
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  • Specification
  • Product Description:
  • LATS1 (Human) ELISA Kit is a sandwich ELISA with highly sensitive and highly specific for the detection of LATS1 in human serum, plasma, tissue lysates and other biological fluids.
  • Calibration Range:
  • 0.156 - 10 ng/mL
  • Limit of Detection:
  • 0.094 ng/mL
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Standard curve

    QC Testing of KA6398
    The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
  • Storage Instruction:
  • Stored at 4°C.
  • Suitable Sample:
  • Human serum, plasma, tissue lysates and other biological fluids
  • Sample Volume:
  • 100 uL
  • Label:
  • HRP-conjugate
  • Detection Method:
  • Colorimetric
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Quantification
  • Application Image
  • Quantification
  • Gene Information
  • Entrez GeneID:
  • 9113
  • Gene Name:
  • LATS1
  • Gene Alias:
  • WARTS,wts
  • Gene Description:
  • LATS, large tumor suppressor, homolog 1 (Drosophila)
  • Gene Summary:
  • The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq
  • Other Designations:
  • LATS (large tumor suppressor, Drosophila) homolog 1,LATS homolog 1
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