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Qualitative

Entrez GeneID

Protein Accession#

Gene Name

ZIC1

Gene Alias

ZIC, ZNF201

Gene Description

Zic family member 1 (odd-paired homolog, Drosophila)

Omim ID

Gene Ontology

Gene Summary

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq

Other Designations

Zic family member 1 (odd-paired Drosophila homolog)|Zinc finger protein of the cerebellum 1|zinc finger protein of the cerebellum 1

Entrez GeneID

Protein Accession#

Gene Name

ZIC2

Gene Alias

HPE5

Gene Description

Zic family member 2 (odd-paired homolog, Drosophila)

Omim ID

Gene Ontology

Gene Summary

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq

Other Designations

OTTHUMP00000018633|Zic family member 2 (odd-paired Drosophila homolog)|Zinc finger protein of the cerebellum 2|zinc finger protein of the cerebellum 2

Entrez GeneID

Protein Accession#

Gene Name

ZIC3

Gene Alias

HTX, HTX1, ZNF203

Gene Description

Zic family member 3 (odd-paired homolog, Drosophila)

Omim ID

Gene Ontology

Gene Summary

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq

Other Designations

OTTHUMP00000024142|heterotaxy 1|zinc finger protein of the cerebellum 3