PDGFB (Human) ELISA Kit

Product Description:
PDGFB (Human) ELISA Kit is a sandwich enzyme-linked immunosorbent assay for the quantitative measurement of human PDGFB in cell culture supernatants, serum and plasma (heparin, EDTA).

Quality Control Testing:
Standard curve

The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.

Storage Instruction:
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.

Gene Description:
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

Gene Summary:
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq

Other Designations:
PDGF, B chain,Platelet-derived growth factor, beta polypeptide (oncogene SIS),becaplermin,oncogene SIS,platelet-derived growth factor 2,platelet-derived growth factor beta,platelet-derived growth factor, B chain,v-sis platelet-derived growth factor beta p