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Entrez GeneID

Protein Accession#

Gene Name

SEMA6D

Gene Alias

FLJ11598, KIAA1479

Gene Description

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

Omim ID

Gene Ontology

Gene Summary

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Six transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq

Other Designations

semaphorin 6D