SIRPA (Human) Cell-Based ELISA Kit
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Specification
Product Description
SIRPA (Human) Cell-Based ELISA Kit is an indirect enzyme-linked immunoassay for qualitative determination of Sirp alpha1 expression in cultured cells.
Suitable Sample
Attached cell, loosely attached cell and suspension cell
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Qualitative
Reactivity
Human
Regulatory Status
For research use only (RUO)
Storage Instruction
Store at 4°C for six months.
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Applications
Qualitative
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Gene Info — SIRPA
Entrez GeneID
140885Protein Accession#
P78324Gene Name
SIRPA
Gene Alias
BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS-1, SHPS1, SIRP, SIRP-ALPHA-1, SIRPalpha, SIRPalpha2
Gene Description
signal-regulatory protein alpha
Omim ID
602461Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000030001|SHP substrate-1|brain-immunoglobulin-like molecule with tyrosine-based activation motifs|macrophage fusion receptor|myd-1 antigen|protein tyrosine phosphatase, non-receptor type substrate 1|signal regulatory protein, alpha type 1|signal
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