UMOD (Human) ELISA Kit
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Specification
Product Description
UMOD (Human) ELISA Kit is a sandwich enzyme-linked immunosorbent assay for quantitative detection of human Uromodulin in cell culture supernates, serum and plasma (heparin, EDTA).
Suitable Sample
Cell culture supernates, Serum and Plasma (heprain, EDTA)
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
312 to 20000 pg/mL
Reactivity
Human
Regulatory Status
For research use only (RUO)
Storage Instruction
Store at 4°C for six months. For long term storage store at -20°C.
Avoid repeated freezing and thawing. -
Applications
Quantification
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Gene Info — UMOD
Entrez GeneID
7369Gene Name
UMOD
Gene Alias
ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP
Gene Description
uromodulin
Gene Ontology
HyperlinkGene Summary
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq
Other Designations
OTTHUMP00000162212|Tamm-Horsfall glycoprotein|uromodulin (uromucoid, Tamm-Horsfall glycoprotein)|uromucoid
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