DAG1 (Human) ELISA Kit
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The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
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Specification
Product Description
DAG1 (Human) ELISA Kit is a sandwich enzyme-linked immunosorbent assay for quantitative detection of human dystroglycan in cell culture supernates, serum, plasma (heparin, EDTA), saliva and urine.
Suitable Sample
Cell culture supernates, serum, plasma (heparin, EDTA), saliva and urine
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
156 to 10000 pg/mL
Reactivity
Human
Regulatory Status
For research use only (RUO)
Quality Control Testing
Standard curve
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction
Store at 4°C for six months. For long term storage store at -20°C.
Avoid repeated freezing and thawing. -
Applications
Quantification
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Gene Info — DAG1
Entrez GeneID
1605Gene Name
DAG1
Gene Alias
156DAG, A3a, AGRNR, DAG
Gene Description
dystroglycan 1 (dystrophin-associated glycoprotein 1)
Omim ID
128239Gene Ontology
HyperlinkGene Summary
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants
Other Designations
alpha-dystroglycan|beta-dystroglycan|dystroglycan 1|dystrophin-associated glycoprotein-1
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Interactome
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Pathway
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Disease
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