TPSB2 (Human) ELISA Kit
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Specification
Product Description
TPSB2 (Human) ELISA Kit is a sandwich enzyme-linked immunosorbent assay for the quantitative measurement of human TPSB2.
Suitable Sample
Cell Culture Supernatant, Cell Lysates, Plasma (EDTA, Heparin), Serum
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
156 to 10000 pg/mL
Reactivity
Human
Regulatory Status
For research use only (RUO)
Quality Control Testing
Standard curve
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — TPSB2
Entrez GeneID
64499Protein Accession#
P20231Gene Name
TPSB2
Gene Alias
TPS2, TPSB1, tryptaseC
Gene Description
tryptase beta 2
Omim ID
191081Gene Ontology
HyperlinkGene Summary
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq
Other Designations
beta II|beta III|lung tryptase|mast cell protease I|mast cell tryptase|pituitary tryptase|skin tryptase|tryptase II|tryptase III|tryptase beta II|tryptase beta III|tryptaseB
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