Anti-Pembrolizumab (Human) ELISA Kit is a sandwich enzyme-linked immunoassay for the qualitative measurement of antibody against Pembrolizumab in human serum or plasma. Target gene is PD-1.
Reactivity:
Human
Storage Instruction:
Store the kit at 4°C.
Note:
Pembrolizumab infusion camouflages/masks the presence of antibody to Pembrolizumab (ATP) in serum/plasma samples. Therefore, blood sampling time is critical for detection of ATP. It is convenient to obtain blood sample just before the infusion or at least 2 weeks after the infusion of Pembrolizumab.
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq