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Last updated: 2016/11/27

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Phosphotyrosine JAK1 (Human) ELISA Kit

  • Catalog # : KA4669
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  • Specification
  • Product Description:
  • Phosphotyrosine JAK1 (Human) ELISA Kit is an enzyme-linked immunosorbent assay for qualitative determination of human phosphotyrosine JAK1.
  • Reactivity:
  • Human
  • Storage Instruction:
  • Store the kit at-20°C.
  • Suitable Sample:
  • Cell Lysate, Tissue Lysate
  • Sample Volume:
  • 100 uL
  • Label:
  • Biotin-conjugate
  • Detection Method:
  • Colorimetric
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Qualitative
  • Application Image
  • Qualitative
  • Gene Information
  • Entrez GeneID:
  • 3716
  • Gene Name:
  • JAK1
  • Gene Alias:
  • JAK1A,JAK1B,JTK3
  • Gene Description:
  • Janus kinase 1 (a protein tyrosine kinase)
  • Gene Summary:
  • Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000010896,janus kinase 1
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