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Functional Study

Entrez GeneID

Gene Name

MAN2C1

Gene Alias

DKFZp686E23167, MAN6A8, MANA, MANA1, MGC87979

Gene Description

mannosidase, alpha, class 2C, member 1

Omim ID

Gene Ontology

Gene Summary

mannosidase

Other Designations

mannosidase, alpha 6A8|mannosidase, alpha A, cytoplasmic

Entrez GeneID

Gene Name

MAN2B1

Gene Alias

LAMAN, MANB

Gene Description

mannosidase, alpha, class 2B, member 1

Omim ID

Gene Ontology

Gene Summary

This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. [provided by RefSeq

Other Designations

lysosomal acid alpha-mannosidase|mannosidase, alpha B, lysosomal

Entrez GeneID

Gene Name

MAN2B2

Gene Alias

KIAA0935

Gene Description

mannosidase, alpha, class 2B, member 2

Gene Ontology

Gene Summary

mannosidase

Other Designations

core-specific lysosomal alpha-1,6-Mannosidase|epididymis-specific alpha-mannosidase