SIRT6 Deacetylase Fluorometric (Human) Assay Kit is designed for the rapid and sensitive detection of deacetylase activity of recombinant SIRT6 and evaluation of SIRT6 inhibitors or activators using crude SIRT6 fraction or purified SIRT6.
Quality Control Testing:
Dose dependent curve
Dose dependent curve of recombinant SIRT6 activity.
Store the kit at -80°C. Do not expose reagents to excessive light.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq
sir2-related protein type 6,sirtuin 6,sirtuin type 6