SIRT3 Deacetylase Fluorometric (Human) Assay Kit
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More Files
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Dose dependent curve of recombinant SIRT3 activity.
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Specification
Product Description
SIRT3 Deacetylase Fluorometric (Human) Assay Kit is designed for the rapid and sensitive evaluation of SIRT3 inhibitors or activators using crude SIRT3 fraction or purified SIRT3. Additionally, any cultured primary cell, cell line, or tissue homogenate can be assayed for SIRT3 activity with the SIRT3 deacetylase fluorometric assay kit after immunoprecipitation with an appropriate SIRT3 specific antibody.
Reactivity
Human
Regulation Status
For research use only (RUO)
Quality Control Testing
Dose dependent curve
Dose dependent curve of recombinant SIRT3 activity.
Storage Instruction
Store the kit at -80°C. Do not expose reagents to excessive light.
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Applications
Functional Study
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Gene Info — SIRT3
Entrez GeneID
23410Gene Name
SIRT3
Gene Alias
SIR2L3
Gene Description
sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)
Omim ID
604481Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq
Other Designations
mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase|silent mating type information regulation 2, S.cerevisiae, homolog 3|sir2-like 3|sirtuin 3|sirtuin type 3
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Interactome
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Disease
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Publication Reference
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Oscillatory shear stress-mediated aberrant O-GlcNAc SIRT3 accelerates glycocalyx inflammatory injury via LKB1/p47phox/Hyal2 signaling.
Lei Zhang, Jiajia Li, Jun Chen, Jin Lei, Zhiyi Yuan, Jun Zhang, Zhaohong Liu, Chao Yu, Limei Ma.
Cellular Signalling 2023 Sep; 109:110790.
Application：Func, Human, HEK293T cells.
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Oscillatory shear stress-mediated aberrant O-GlcNAc SIRT3 accelerates glycocalyx inflammatory injury via LKB1/p47phox/Hyal2 signaling.
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