HDAC8 Deacetylase Fluorometric (Human) Assay Kit is designed for the rapid and sensitive evaluation of HDAC inhibitors using recombinant HDAC8. Additionally, any cultured primary cell, cell line, or tissue homogenate can be assayed for HDAC8 activity with the HDAC8 deacetylase fluorometric assay kit after immunoprecipitation with an appropriate HDAC8 specific antibody.
Quality Control Testing:
Dose dependent curve
Dose dependent curve of recombinant HDAC8.
Store the kit at -80°C. Do not expose reagents to excessive light.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. [provided by RefSeq