MMP12 (Human) ELISA Kit
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Specification
Product Description
MMP12 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human MMP12.
Suitable Sample
Cell culture supernates, Plasma (heparin), Serum
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
62.5 to 4000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Quality Control Testing
Standard Curve
The standard curve is for the purpose of demonstration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — MMP12
Entrez GeneID
4321Gene Name
MMP12
Gene Alias
HME, MGC138506, MME
Gene Description
matrix metallopeptidase 12 (macrophage elastase)
Omim ID
601046Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Other Designations
macrophage elastase|macrophage metalloelastase|matrix metalloproteinase 12|matrix metalloproteinase 12 (macrophage elastase)
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Interactome
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Disease
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Publication Reference
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Cardiovascular protection in females linked to estrogen-dependent inhibition of arterial stiffening and macrophage MMP12.
Liu SL, Bajpai A, Hawthorne EA, Bae Y, Castagnino P, Monslow J, Puré E, Spiller KL, Assoian RK.
JCI Insight 2019 Jan; 4(1):122742.
Application:ELISA, Human, M0 cells.
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MMP-12 and S100s in saliva reflect different aspects of periodontal inflammation.
Holmström SB, Lira-Junior R, Zwicker S, Majster M, Gustafsson A, Åkerman S, Klinge B, Svensson M, Boström EA.
Cytokine 2019 Jan; 113:155.
Application:ELISA, Human, Salivary.
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Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200Rlow Monocyte-Derived Cells in Periodontitis.
Björnfot Holmström S, Clark R, Zwicker S, Bureik D, Kvedaraite E, Bernasconi E, Nguyen Hoang AT, Johannsen G, Marsland BJ, Boström EA, Svensson M.
Journal of immunology 2017 Dec; 199(12):4023.
Application:Quant, Human, Monocytes-derived cells.
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Cardiovascular protection in females linked to estrogen-dependent inhibition of arterial stiffening and macrophage MMP12.
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