TNFSF11 (Human) ELISA Kit
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
TNFSF11 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human TNFSF11.
Suitable Sample
Cell culture supernates, Cell Lysates, Plasma (heparin, EDTA), Serum
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
78 to 5000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
-
Applications
Quantification
-
Gene Info — TNFSF11
Entrez GeneID
8600Gene Name
TNFSF11
Gene Alias
CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
Gene Description
tumor necrosis factor (ligand) superfamily, member 11
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq
Other Designations
OTTHUMP00000178585|TNF-related activation-induced cytokine|osteoclast differentiation factor|osteoprotegerin ligand|receptor activator of nuclear factor kappa B ligand|tumor necrosis factor ligand superfamily, member 11
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
hMSC-derived VEGF release triggers the chemoattraction of alveolar osteoblasts.
Proksch S, Bittermann G, Vach K, Nitschke R, Tomakidi P, Hellwig E.
Stem Cells 2015 Oct; 33(10):3114.
Application:S-ELISA, Human, Supernatants collected from Human bone marrow-derived mesenchymal stem cells.
-
hMSC-derived VEGF release triggers the chemoattraction of alveolar osteoblasts.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com