KLKB1 (Human) ELISA Kit
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Specification
Product Description
KLKB1 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human KLKB1.
Suitable Sample
Cell Culture Supernatant, CSF, Milk, Plasma, Saliva, Serum
Sample Volume
50 uL
Label
Peroxidase-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
1.25 to 80.0 ng/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store components of the kit at 4°C or -20°C as described in the protocol.
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Applications
Quantification
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Gene Info — KLKB1
Entrez GeneID
3818Gene Name
KLKB1
Gene Alias
KLK3, PPK
Gene Description
kallikrein B, plasma (Fletcher factor) 1
Omim ID
229000Gene Ontology
HyperlinkGene Summary
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq
Other Designations
Kallikrein, plasma|kallikrein 3, plasma|kallikrein B plasma|kininogenin|plasma kallikrein B1
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Interactome
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Pathway
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Publication Reference
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A group of serum proteins as potential diagnostic biomarkers for Yin-deficiency-heat syndrome.
Chen J, Jiang TT, Yi WJ, Jiao JL, Liu CM, Tu HH, Hu YT, Shi LY, Huang H, Li ZB, Gan L, Li ZJ, Li JC.
Anatomical Record (Hoboken, N.J. : 2007) 2020 Aug; 303(8):2086.
Application:Quant, Human, Human serum.
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A group of serum proteins as potential diagnostic biomarkers for Yin-deficiency-heat syndrome.
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