CFB (Human) ELISA Kit
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Specification
Product Description
CFB (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human CFB.
Suitable Sample
Cell Culture Supernatant, Cell Lysate, CSF, Milk, Plasma, Saliva, Serum
Sample Volume
50 uL
Label
Peroxidase-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
2.188 to 140 ng/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store components of the kit at 4°C or -20°C as described in the protocol.
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Applications
Quantification
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Gene Info — CFB
Entrez GeneID
629Gene Name
CFB
Gene Alias
BF, BFD, CFAB, FB, FBI12, GBG, H2-Bf, PBF2
Gene Description
complement factor B
Gene Ontology
HyperlinkGene Summary
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq
Other Designations
B-factor, properdin|C3 proaccelerator|C3 proactivator|C3/C5 convertase|OTTHUMP00000029283|OTTHUMP00000174690|glycine-rich beta-glycoprotein
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Interactome
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Pathway
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Disease
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Publication Reference
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Resveratrol delays polycystic kidney disease progression through attenuation of nuclear factor κB-induced inflammation.
Wu M, Gu J, Mei S, Xu D, Jing Y, Yao Q, Chen M, Yang M, Chen S, Yang B, Qi N, Hu H, Wuthrich RP and Mei C.
Nephrology, Dialysis, Transplantation 2016 Apr; 31(11):1826.
Application:Quan, Human, OX161 cell.
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Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
Jiang K, Ma XP, Yu H, Cao G, Ding DL, Chen H, Huang HX, Gao YZ, Wu XP, Long XD, Zhang H, Zhang Y, Gao Y, Chen TY, Ren WH, Zhang P, Shi Z, Jiang W, Wan B, Saiyin H, Yin J, Zhou YF, Zhai Y, Lu PX, Zhang H, Gu X, Tan A, Wang JB, Zuo XB, Sun LD, Liu JO, Yi Q, Mo Z, Zhou G, Liu Y, Sun J, Shugart YY, Zheng SL, Zhang XJ, Xu J, Yu L.
Hepatology (Baltimore, Md.) 2015 Jul; 62(1):118.
Application:ELISA, Human, Plasma.
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Resveratrol delays polycystic kidney disease progression through attenuation of nuclear factor κB-induced inflammation.
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