ESPL1 (Human) Cell-Based ELISA Kit
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Specification
Product Description
ESPL1 (Human) Cell-Based ELISA Kit is an indirect enzyme-linked immunoassay for qualitative determination of ESPL1 expression in cultured cells.
Suitable Sample
Attached Cell, Loosely Attached Cell, Suspension Cell
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Qualitative
Reactivity
Human, Mouse
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at 4°C.
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Applications
Qualitative
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Gene Info — ESPL1
Entrez GeneID
9700Gene Name
ESPL1
Gene Alias
ESP1, FLJ46492, KIAA0165, SEPARASE, SEPARIN
Gene Description
extra spindle pole bodies homolog 1 (S. cerevisiae)
Omim ID
604143Gene Ontology
HyperlinkGene Summary
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 604359) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM
Other Designations
extra spindle poles like 1|separin, separase
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