Products

Qualitative

Entrez GeneID

Gene Name

PML

Gene Alias

MYL, PP8675, RNF71, TRIM19

Gene Description

promyelocytic leukemia

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq

Other Designations

promyelocytic leukemia protein|promyelocytic leukemia, inducer of|tripartite motif protein TRIM19