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Entrez GeneID

Gene Name

FURIN

Gene Alias

FUR, PACE, PCSK3, SPC1

Gene Description

furin (paired basic amino acid cleaving enzyme)

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq

Other Designations

FES upstream region|dibasic processing enzyme|furin|furin, membrane associated receptor protein|paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein)|proprotein convertase subtilisin/kexin type 3