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MAP2K1/MAP2K2 (Human) Cell-Based ELISA Kit

  • Catalog # : KA2917
  • Visit Frequency :
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  • Specification
  • Product Description:
  • MAP2K1/MAP2K2 (Human) Cell-Based ELISA Kit is an indirect enzyme-linked immunoassay for qualitative determination of MAP2K1/MAP2K2 expression in cultured cells.
  • Reactivity:
  • Human, Mouse, Rat
  • Storage Instruction:
  • Store the kit at 4°C.
  • Suitable Sample:
  • Attached Cell, Loosely Attached Cell, Suspension Cell
  • Label:
  • HRP-conjugated
  • Detection Method:
  • Colorimetric
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Qualitative
  • Application Image
  • Qualitative
  • Gene Information
  • Entrez GeneID:
  • 5604
  • Protein Accession#:
  • Q02750 (Gene ID : 5604);P36507 (Gene ID : 5605)
  • Gene Name:
  • MAP2K1
  • Gene Alias:
  • MAPKK1,MEK1,MKK1,PRKMK1
  • Gene Description:
  • mitogen-activated protein kinase kinase 1
  • Gene Summary:
  • The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq
  • Other Designations:
  • protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
  • Gene Information
  • Entrez GeneID:
  • 5605
  • Protein Accession#:
  • Q02750 (Gene ID : 5604);P36507 (Gene ID : 5605)
  • Gene Name:
  • MAP2K2
  • Gene Alias:
  • FLJ26075,MAPKK2,MEK2,MKK2,PRKMK2
  • Gene Description:
  • mitogen-activated protein kinase kinase 2
  • Gene Summary:
  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq
  • Other Designations:
  • ERK activator kinase 2,MAP kinase kinase 2,MAPK/ERK kinase 2,dual specificity mitogen-activated protein kinase kinase 2,mitogen-activated protein kinase kinase 2, p45
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