FGFR3 (Human) Cell-Based ELISA Kit
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Specification
Product Description
FGFR3 (Human) Cell-Based ELISA Kit is an indirect enzyme-linked immunoassay for qualitative determination of FGFR3 expression in cultured cells.
Suitable Sample
Attached Cell, Loosely Attached Cell, Suspension Cell
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Qualitative
Reactivity
Human, Mouse, Rat
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at 4°C.
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Applications
Qualitative
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Gene Info — FGFR3
Entrez GeneID
2261Protein Accession#
P22607Gene Name
FGFR3
Gene Alias
ACH, CD333, CEK2, HSFGFR3EX, JTK4
Gene Description
fibroblast growth factor receptor 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000149959|achondroplasia, thanatophoric dwarfism|hydroxyaryl-protein kinase|tyrosine kinase JTK4
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