CREBBP (Human) Cell-Based ELISA Kit
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Specification
Product Description
CREBBP (Human) Cell-Based ELISA Kit is an indirect enzyme-linked immunoassay for qualitative determination of CREBBP expression in cultured cells.
Suitable Sample
Attached Cell, Loosely Attached Cell, Suspension Cell
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Qualitative
Reactivity
Human, Mouse
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at 4°C.
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Applications
Qualitative
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Gene Info — CREBBP
Entrez GeneID
1387Protein Accession#
Q92793Gene Name
CREBBP
Gene Alias
CBP, KAT3A, RSTS
Gene Description
CREB binding protein
Gene Ontology
HyperlinkGene Summary
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
Rubinstein-Taybi syndrome
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Interactome
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Pathway
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Disease
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