CCR5 (Human) Cell-Based ELISA Kit
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Specification
Product Description
CCR5 (Human) Cell-Based ELISA Kit is an indirect enzyme-linked immunoassay for qualitative determination of CCR5 expression in cultured cells.
Suitable Sample
Attached Cell, Loosely Attached Cell, Suspension Cell
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Qualitative
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at 4°C.
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Applications
Qualitative
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Gene Info — CCR5
Entrez GeneID
1234Protein Accession#
P51681Gene Name
CCR5
Gene Alias
CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Gene Description
chemokine (C-C motif) receptor 5
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
C-C chemokine receptor 5|C-C chemokine receptor type 5|CCR5 chemokine receptor|chemokine (C-C) receptor 5|chemokine receptor CCR5|chemr13
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Interactome
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Pathway
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Disease
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Publication Reference
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CCR5 receptor antagonism inhibits hepatitis C virus (HCV) replication in vitro.
Blackard JT, Kong L, Rouster SD, Karns R, Horn PS, Kottilil S, Shata MT, Sherman KE.
PLoS One 2019 Oct; 14(10):e0224523.
Application:Quant, Human, Huh7.5 cells.
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CCR5 receptor antagonism inhibits hepatitis C virus (HCV) replication in vitro.
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